Precision Organoid Intelligence · Johns Hopkins spinout

Test on a human brain.
Before you test on humans.

Vascularized, multi-region brain organoids for CNS drug discovery — grown from human stem cells.

NEURAL ACTIVITY
The problem

The brain is the hardest organ to drug.

Animal models
A mouse brain isn't a human brain.
Flat cultures
Cells in a dish don't form circuits.
The cost
Failure arrives late — after the spend.
The platform · MRBO

So we grew a better one.

The Multi-Region Brain Organoid — living human brain tissue, engineered to behave like the real thing.

Multi-region

Regions that talk.

Distinct brain regions, wired into working circuits — not isolated cells.

Vascularized

Blood vessels, built in.

A vascular network feeds the tissue, so it lives longer and behaves like an organ.

Human

From human stem cells.

Built from human iPSCs — your biology, not a stand-in species.

The readout · NIS™

Every compound. One number.

AI reads the organoid's electrical activity and returns a single Neural Impact Score — so effect, and risk, are legible at a glance.

Neural Impact ScoreNIS™
+0.0scale −4 to +4 · sample readout
−4 · Harmful0Beneficial · +4
Where it goes

From drug discovery to human performance.

01
Screen on human tissue.
Pharma compound screening
02
Organoids on demand.
Living-tissue supply
03
Our science, your bench.
Platform & kit licensing
04
Patient to therapy.
Companion diagnostics
05
Resilience, measured.
Cognitive & performance
06
The brain, on record.
Neural datasets
The proof

Born at Johns Hopkins.
Proven in peer review.

Johns Hopkins spinout
Published · Advanced Science, 2025
Patent pending
The vision · TEDxBoston

A new era in neuroregeneration.

Dr. Annie Kathuria — A new era in neuroregeneration, TEDxBoston TEDx · 2025
Featured video — Dr. Annie Kathuria Watch
Featured video — Dr. Annie Kathuria Watch
Dr. Annie Kathuria · Founder & President, Organotics — Johns Hopkins University

What if we could regrow the human brain? In this visionary TEDx talk, neuroscientist Dr. Annie Kathuria explores the next frontier in regenerative medicine — the emerging science of brain organoids designed for transplantation. While current treatments can't yet reverse brain damage, Dr. Kathuria outlines a research roadmap showing how this could become possible within our lifetime: developing living, modular brain tissue grown from stem cells that might one day be surgically implanted to restore lost function.

Drawing on experimental data and cross-disciplinary advances, she describes how multi-region brain organoids (MRBOs) with replaceable, region-specific modules could progress from concept to clinic, leveraging GMP-grade stem-cell protocols already proven safe in other FDA-authorized studies. Dr. Kathuria explains why this vision is no longer science fiction, but a plausible next step for neuroscience. Advances in vascularisation, immune compatibility, and neural integration are steadily removing barriers once thought insurmountable — a powerful glimpse into the future of medicine, where brain repair moves from imagination to innovation, and healing the wounded brain becomes a shared scientific goal.

Dr. Annie Kathuria is a neuroscientist, biomedical engineer, and founder of Organotics, a neuro-biotechnology company developing brain organoid platforms for regenerative medicine and next-generation drug discovery. At Johns Hopkins University, she leads research integrating stem-cell biology, neural engineering, and AI to uncover how the brain heals and to design tissue systems that could one day repair it. Her extensive peer-reviewed research in neuroengineering and regenerative biology has been recognised for redefining the boundaries of brain repair and human longevity. Beyond the lab, Dr. Kathuria advocates for innovation and interdisciplinary collaboration, believing that healing the brain is not only a scientific challenge but a profoundly human pursuit.

This talk was given at a TEDx event using the TED conference format but independently organised by a local community. Learn more at ted.com/tedx.

The founders

Built by the people who built the science.

Dr. Annie Kathuria
Dr. Annie Kathuria
Founder & President
Johns Hopkins · Biomedical Engineering & Neurosurgery
Davey Bakhshi
Davey Bakhshi
Co-Founder
Venture, commercial & strategy
Work with us

Bring us your compound.

We'll show you what it does to a human brain.

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